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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HUWE1
All Species:
9.7
Human Site:
T3536
Identified Species:
26.67
UniProt:
Q7Z6Z7
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q7Z6Z7
NP_113584.3
4374
481891
T3536
A
A
S
T
T
V
T
T
P
T
T
A
T
T
T
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001088987
4374
481661
T3536
A
A
S
T
T
V
T
T
P
T
T
A
T
T
T
Dog
Lupus familis
XP_538052
4375
482124
T3537
A
A
S
T
T
V
T
T
P
T
T
A
T
T
T
Cat
Felis silvestris
Mouse
Mus musculus
Q7TMY8
4377
482644
V3537
T
V
A
A
S
T
T
V
T
T
P
T
T
A
T
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001923899
4360
479137
A3534
V
V
A
G
S
T
T
A
S
S
I
I
A
G
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_573059
5146
556842
P4274
N
I
E
E
Q
A
S
P
A
S
G
N
P
A
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_500284
4177
465393
Q3377
L
E
E
C
P
L
G
Q
M
L
N
S
L
R
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8GY23
3681
404981
K2918
Q
L
S
S
R
K
G
K
E
K
V
T
H
V
T
Baker's Yeast
Sacchar. cerevisiae
Q03280
3268
374166
S2505
N
T
F
L
F
I
L
S
E
G
I
I
D
Q
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
99.6
98.7
N.A.
97.7
N.A.
N.A.
N.A.
N.A.
N.A.
81.6
N.A.
33.7
N.A.
26.2
N.A.
Protein Similarity:
100
N.A.
99.7
99.1
N.A.
98.6
N.A.
N.A.
N.A.
N.A.
N.A.
88.4
N.A.
48.4
N.A.
44.3
N.A.
P-Site Identity:
100
N.A.
100
100
N.A.
26.6
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
0
N.A.
0
N.A.
P-Site Similarity:
100
N.A.
100
100
N.A.
40
N.A.
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
20
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
24.4
21.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
41.1
38.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
34
34
23
12
0
12
0
12
12
0
0
34
12
23
0
% A
% Cys:
0
0
0
12
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
12
0
0
% D
% Glu:
0
12
23
12
0
0
0
0
23
0
0
0
0
0
0
% E
% Phe:
0
0
12
0
12
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
12
0
0
23
0
0
12
12
0
0
12
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
12
0
12
% H
% Ile:
0
12
0
0
0
12
0
0
0
0
23
23
0
0
0
% I
% Lys:
0
0
0
0
0
12
0
12
0
12
0
0
0
0
23
% K
% Leu:
12
12
0
12
0
12
12
0
0
12
0
0
12
0
0
% L
% Met:
0
0
0
0
0
0
0
0
12
0
0
0
0
0
0
% M
% Asn:
23
0
0
0
0
0
0
0
0
0
12
12
0
0
0
% N
% Pro:
0
0
0
0
12
0
0
12
34
0
12
0
12
0
0
% P
% Gln:
12
0
0
0
12
0
0
12
0
0
0
0
0
12
0
% Q
% Arg:
0
0
0
0
12
0
0
0
0
0
0
0
0
12
0
% R
% Ser:
0
0
45
12
23
0
12
12
12
23
0
12
0
0
12
% S
% Thr:
12
12
0
34
34
23
56
34
12
45
34
23
45
34
56
% T
% Val:
12
23
0
0
0
34
0
12
0
0
12
0
0
12
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _